Results of clinical trials published in peer reviewed publications may differ from what was previously submitted to regulatory agencies,4 5 6 with the published data being more positive. One study found that such “spin” was common in 72 reports of randomised controlled trials with statistically non significant primary outcomes.13 Similar findings have been reported recently for studies of the accuracy of diagnostic tests.14Peer review is failing to ensure that journal articles contain the key clinical and methodological details that readers need. Reviews of published reports of randomised trials have found common deficiencies in the details of the interventions being evaluated pandora essence,15 16 participant eligibility criteria,17 and outcomes.18 19 Details of study methods are also often inadequate, especially in relation to allocation.
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